Broad-spectrum coronavirus antiviral drug discovery
Identifieur interne : 000B74 ( Main/Exploration ); précédent : 000B73; suivant : 000B75Broad-spectrum coronavirus antiviral drug discovery
Auteurs : Allison L. Totura ; Sina BavariSource :
- Expert Opinion on Drug Discovery [ 1746-0441 ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (effets indésirables), Antiviraux (pharmacologie), Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Découverte de médicament (), Humains, Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Modèles animaux de maladie humaine, Syndrome respiratoire aigu sévère (traitement médicamenteux), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (), Virus du SRAS (isolement et purification).
- MESH :
- effets indésirables : Antiviraux.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient, Virus du SRAS.
- pharmacologie : Antiviraux.
- traitement médicamenteux : Infections à coronavirus, Syndrome respiratoire aigu sévère.
- virologie : Infections à coronavirus, Syndrome respiratoire aigu sévère.
- Animaux, Coronavirus du syndrome respiratoire du Moyen-Orient, Découverte de médicament, Humains, Modèles animaux de maladie humaine, Virus du SRAS.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (adverse effects), Antiviral Agents (pharmacology), Coronavirus Infections (drug therapy), Coronavirus Infections (virology), Disease Models, Animal, Drug Discovery (methods), Humans, Middle East Respiratory Syndrome Coronavirus (drug effects), Middle East Respiratory Syndrome Coronavirus (isolation & purification), SARS Virus (drug effects), SARS Virus (isolation & purification), Severe Acute Respiratory Syndrome (drug therapy), Severe Acute Respiratory Syndrome (virology).
- MESH :
- chemical , adverse effects : Antiviral Agents.
- chemical , pharmacology : Antiviral Agents.
- drug effects : Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- drug therapy : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- methods : Drug Discovery.
- virology : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- Animals, Disease Models, Animal, Humans.
Abstract
Url:
DOI: 10.1080/17460441.2019.1581171
PubMed: 30849247
PubMed Central: 7103675
Affiliations:
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Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Broad-spectrum coronavirus antiviral drug discovery</title><author><name sortKey="Totura, Allison L" sort="Totura, Allison L" uniqKey="Totura A" first="Allison L." last="Totura">Allison L. Totura</name><affiliation><nlm:aff id="AFF0001"></nlm:aff></affiliation></author><author><name sortKey="Bavari, Sina" sort="Bavari, Sina" uniqKey="Bavari S" first="Sina" last="Bavari">Sina Bavari</name><affiliation><nlm:aff id="AFF0001"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">30849247</idno><idno type="pmc">7103675</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103675</idno><idno type="RBID">PMC:7103675</idno><idno type="doi">10.1080/17460441.2019.1581171</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">001768</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001768</idno><idno type="wicri:Area/Pmc/Curation">001768</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001768</idno><idno type="wicri:Area/Pmc/Checkpoint">000483</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000483</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:30849247</idno><idno type="wicri:Area/PubMed/Corpus">000922</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000922</idno><idno type="wicri:Area/PubMed/Curation">000922</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000922</idno><idno type="wicri:Area/PubMed/Checkpoint">000924</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000924</idno><idno type="wicri:Area/Ncbi/Merge">003028</idno><idno type="wicri:Area/Ncbi/Curation">003028</idno><idno type="wicri:Area/Ncbi/Checkpoint">003028</idno><idno type="wicri:doubleKey">1746-0441:2019:Totura A:broad:spectrum:coronavirus</idno><idno type="wicri:Area/Main/Merge">000B75</idno><idno type="wicri:Area/Main/Curation">000B74</idno><idno type="wicri:Area/Main/Exploration">000B74</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Broad-spectrum coronavirus antiviral drug discovery</title><author><name sortKey="Totura, Allison L" sort="Totura, Allison L" uniqKey="Totura A" first="Allison L." last="Totura">Allison L. Totura</name><affiliation><nlm:aff id="AFF0001"></nlm:aff></affiliation></author><author><name sortKey="Bavari, Sina" sort="Bavari, Sina" uniqKey="Bavari S" first="Sina" last="Bavari">Sina Bavari</name><affiliation><nlm:aff id="AFF0001"></nlm:aff></affiliation></author></analytic><series><title level="j">Expert Opinion on Drug Discovery</title><idno type="ISSN">1746-0441</idno><idno type="eISSN">1746-045X</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (adverse effects)</term><term>Antiviral Agents (pharmacology)</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (virology)</term><term>Disease Models, Animal</term><term>Drug Discovery (methods)</term><term>Humans</term><term>Middle East Respiratory Syndrome Coronavirus (drug effects)</term><term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term><term>SARS Virus (drug effects)</term><term>SARS Virus (isolation & purification)</term><term>Severe Acute Respiratory Syndrome (drug therapy)</term><term>Severe Acute Respiratory Syndrome (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antiviraux (effets indésirables)</term><term>Antiviraux (pharmacologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term><term>Découverte de médicament ()</term><term>Humains</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Infections à coronavirus (virologie)</term><term>Modèles animaux de maladie humaine</term><term>Syndrome respiratoire aigu sévère (traitement médicamenteux)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Virus du SRAS ()</term><term>Virus du SRAS (isolement et purification)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Antiviraux</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Drug Discovery</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Découverte de médicament</term><term>Humains</term><term>Modèles animaux de maladie humaine</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>ABSTRACT</title><p><bold>Introduction</bold>: The highly pathogenic coronaviruses severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) are lethal zoonotic viruses that have emerged into human populations these past 15 years. These coronaviruses are associated with novel respiratory syndromes that spread from person-to-person via close contact, resulting in high morbidity and mortality caused by the progression to Acute Respiratory Distress Syndrome (ARDS).</p><p><bold>Areas covered</bold>: The risks of re-emergence of SARS-CoV from bat reservoir hosts, the persistence of MERS-CoV circulation, and the potential for future emergence of novel coronaviruses indicate antiviral drug discovery will require activity against multiple coronaviruses. In this review, approaches that antagonize viral nonstructural proteins, neutralize structural proteins, or modulate essential host elements of viral infection with varying levels of efficacy in models of highly pathogenic coronavirus disease are discussed.</p><p><bold>Expert opinion</bold>: Treatment of SARS and MERS in outbreak settings has focused on therapeutics with general antiviral activity and good safety profiles rather than efficacy data provided by cellular, rodent, or nonhuman primate models of highly pathogenic coronavirus infection. 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Martina</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bavari, Sina" sort="Bavari, Sina" uniqKey="Bavari S" first="Sina" last="Bavari">Sina Bavari</name><name sortKey="Totura, Allison L" sort="Totura, Allison L" uniqKey="Totura A" first="Allison L." last="Totura">Allison L. 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